Impact of COVID-19 on Liver Enzymes: A Retrospective Study

Introduction: The global pandemic of novel Coronavirus Disease- 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has spread worldwide crippling the healthcare system. Besides respiratory system, COVID-19 patients show signs various degrees liver damage, mechanism and implication yet undeciphered. Hence, in this study, we aim to find out pattern trend derangement functions patients. Aim: To depict enzymes COVID- 19 admitted without history disease. Materials Methods: study was conducted as a single centred, retrospective, observational from June 2020 till December 2020. It included 1909 positive diagnosed via either nasopharyngeal or oropharyngeal swab Real-Time Reverse Transcription-Polymerase Chain Reaction (RT-PCR). were divided into four groups Group I: Age- 15-20 years; 150 patients, II: Age 21-40 645 III: 41-60 560 IV: >60 554 Abnormality tests defined greater than three times upper limit normal reference range Alanine Transaminase (ALT) >120 U/L, Aspartate (AST) U/L Hepatocellular injury, two Alkaline Phosphatase (ALP) >250 Cholestatic Injury (CSI). statistical analysis done Statistical Package for Social Sciences (SPSS) version 25.0. Results: found that with respect ALT levels, males age 21-60 years, whereas females extremes years most affected. Whereas, group <40 more affected higher AST activity. With abnormal ALP levels female but >40 years. Conclusion: Irrespective gender, abnormality observed. Liver Function Tests (LFT) are part routine investigations carried at time admission; its abnormalities may guide us devising strategy prioritise patient management correlation inflammatory markers.